Research Associate or Post-Doctoral Fellow
Epidemiology/Pharmacoepidemiology/Biostatistics,
Department of Medicine (Division of Neurology),
University of British Columbia (UBC), Vancouver, Canada
Funding source: Various
Anticipated starting date: Spring / summer 2009
Location: Faculty of Medicine, Department of Medicine, Division of Neurology, UBC, Vancouver, Canada.
Salary: Salary is commensurate with experience and qualifications in accordance with the University of British Columbia guidelines.
An opportunity of a life-time
An exciting opportunity has arising for a suitably qualified candidate to join our research team at the University of British Columbia.
At the University of British Columbia, Canada, we house one of the largest longitudinal population-based MS databases in the world. The high prevalence rates of MS in BC (currently affecting an estimated 240 per 105) provides our British Columbia-wide MS (‘BCMS’) database (established in 1980 by Dr Don Paty) with a substantial pool of patients. The database currently holds over 7500 patients followed for over 25 years. Approximately 1500 MS patients are seen each year within the BC MS clinics.
The successful applicant will contribute to a new 4-year project entitled: ‘The BeAMS Study Long-term Benefits and Adverse Effects of Beta-interferon for Multiple Sclerosis.’
The successful applicant will utilise the BC-wide multiple sclerosis database and other provincial health and drug databases to establish the long-term effectiveness and risks of a widely accepted class of treatments for MS, with a long-term objective of encouraging and facilitating the emergence and monitoring of novel MS treatments. The successful candidate will become involved in one or more of the project themes: drug effectiveness, adverse event monitoring, medical services utilization and employment outcomes.
There is also considerable scope for the applicant to initiate new avenues of research within the field of MS, based on their previous training and research interests. The successful applicant will be involved with all aspects of epidemiological research from study design, grant writing, planning, ensuring integrity of data, data linkage, patient chart reviews, executing and interpreting statistical analyses, presentation of findings both verbally and in table/graph form, drafting and publication of scientific manuscripts.
The successful candidate will have demonstrated potential to excel in their field of research and will have excellent organizational ability, verbal and written communication skills. A track record of first-author publications in peer-review journals and previous experience with grant writing is required. Must be able to demonstrate ability to plan and complete work assignments independently. Knowledge of recent advances in pharmacological studies required; previous involvement in such studies an asset. Use of statistical software and Kaplan-Meier/time-dependent Cox proportional hazards model for survival analysis and propensity scores an asset. Knowledge of MS an asset. The successful candidate may supervise students and other research personnel.
Open to applicants holding a PhD in epidemiology/ pharmacoepidemiology/biostatistics or other equivalent qualifications or work experience in their field of research.
UBC Hires on the basis of merit and is committed to employment equity. We encourage all qualified persons to apply. However, Canadians and permanent residents of Canada will be given priority.
The Lifestyle
Beautiful British Columbia is situated on the West Coast of Canada. Vancouver itself is nestled at the foot of the inspiring North Shore Mountains. The climate’s great and perfect for the outdoor enthusiast. You can ski at Whistler during the winter (and still play golf in Vancouver) and hike, bike and sail all summer. Swim in one of our outdoor pools before work or snowboard on the local mountains after work.
Please send a cover letter, PDF copies of three publications and CV, quoting the reference: BeAMSUBCMedicine to:
Dr. Helen Tremlett (tremlett@interchange.ubc.ca)
The position will remain open until filled. For further questions, please contact Dr Helen Tremlett.
web-site: http://www.ubcneurology.com/Staff%20Web%20Pages/Htremlett.htm
Scientific, Biological, Medical job information in Great Vancouver
Thursday, March 19, 2009
Faculty Position, Division of Endocrinology, Department of Medicine UBC
The Division of Endocrinology, Department of Medicine of the University of British Columbia is seeking an outstanding physician for a full-time grant tenure-track position at the Associate Professor level in endocrinology. The successful candidate must hold an FRCP (C) or equivalent in Internal Medicine with a Certificate of Special Competence in Endocrinology, have completed an accredited fellowship in endocrinology, and be eligible to practice as a specialist endocrinologist in British Columbia. Candidates are expected to develop an active program in laboratory or clinical research, and will preferably hold a post-graduate degree or equivalent qualification in health or life sciences. Preference will be given to candidates with a proven track record in thyroid and pituitary medicine. The successful candidate will have demonstrated excellence in teaching and will be expected to participate in the undergraduate as well as post graduate teaching activities of the Division. The successful applicant will become Director of the Thyroid Clinic at St. Paul’s Hospital.
The Division comprises 16 academic endocrinologists engaged in clinical medicine, education and research with a full range of medical and surgical resources, institutional facilities and support staff. The University of British Columbia, located in a region of natural beauty, is recognized as one of North America’s leading medical research universities.
UBC hires on the basis of merit and is committed to employment equity. We encourage all qualified persons to apply, however, Canadians and permanent residents of Canada will be given priority.
Salaries are commensurate with qualifications and experience. Closing date for applications is April 30, 2009.
Applications, including curriculum vitae, description of specialized training, educational / research interests, a teaching dossier, representative publications, and names and addresses of four referees should be sent to:
Dr. E. Ur, Professor and Head
UBC Division of Endocrinology
#4116 Diamond Health Care Centre
2775 Laurel Street, Vancouver, BC, V5Z 1M9
Email: aallen@providencehealth.bc.ca
The Division comprises 16 academic endocrinologists engaged in clinical medicine, education and research with a full range of medical and surgical resources, institutional facilities and support staff. The University of British Columbia, located in a region of natural beauty, is recognized as one of North America’s leading medical research universities.
UBC hires on the basis of merit and is committed to employment equity. We encourage all qualified persons to apply, however, Canadians and permanent residents of Canada will be given priority.
Salaries are commensurate with qualifications and experience. Closing date for applications is April 30, 2009.
Applications, including curriculum vitae, description of specialized training, educational / research interests, a teaching dossier, representative publications, and names and addresses of four referees should be sent to:
Dr. E. Ur, Professor and Head
UBC Division of Endocrinology
#4116 Diamond Health Care Centre
2775 Laurel Street, Vancouver, BC, V5Z 1M9
Email: aallen@providencehealth.bc.ca
ASSISTANT PROFESSOR, INFECTIOUS DISEASES - UBC and VCH
The University of British Columbia, Department of Medicine, Division of Infectious Diseases invites applications for a Clinician Scientist/Assistant Professor to begin September 1, 2009. This tenure track position is subject to budgetary approval. As a clinician with or eligible for RCPSC certification in Infectious Diseases, the successful candidate will provide inpatient and outpatient services at Vancouver General Hospital (Vancouver Coastal Health) along with teaching of undergraduate and postgraduate medical trainees. This will involve an approximate time commitment not to exceed 25%. As a full time faculty member, you will be required to participate on appropriate UBC committees. The remaining time will be committed to developing a basic research program focusing on the molecular pathogenesis of infection or host defense.
The successful applicant will have had a minimum of two years of postgraduate clinical experience and references demonstrating excellence in providing acute care to inpatients in a teaching hospital setting, as well as a demonstrated aptitude for teaching. A minimum of three years of relevant post-doctoral research training with clear evidence of potential to develop and independent research program is also required.
UBC hires on the basis of merit and is committed to employment equity. We encourage all qualified persons to apply, however, Canadians and permanent residents of Canada will be given priority. Interested individuals should submit by a CV, letter describing research interests and plans, and names and complete addresses of three referees to:
Dr. Neil Reiner Head Division of Infectious Diseases,Department of MedicineUBC and VCH604 875 - 4011ethan@interchange.ubc.ca
The successful applicant will have had a minimum of two years of postgraduate clinical experience and references demonstrating excellence in providing acute care to inpatients in a teaching hospital setting, as well as a demonstrated aptitude for teaching. A minimum of three years of relevant post-doctoral research training with clear evidence of potential to develop and independent research program is also required.
UBC hires on the basis of merit and is committed to employment equity. We encourage all qualified persons to apply, however, Canadians and permanent residents of Canada will be given priority. Interested individuals should submit by a CV, letter describing research interests and plans, and names and complete addresses of three referees to:
Dr. Neil Reiner Head Division of Infectious Diseases,Department of MedicineUBC and VCH604 875 - 4011ethan@interchange.ubc.ca
UBC Dept. Pharmacolofy Graduate Student Position
A graduate student position (Pharmacology) under the supervision of Dr. Pascal Bernatchez at St. Paul’s Hospital in downtown Vancouver is currently available. Applicants should hold an undergraduate degree in life sciences (or close to completion). The projects consist in developing new pharmacological approaches for the treatment of cardiovascular diseases. More precisely, the successful candidate will be expected to deepen his understanding and perform experiments related to endothelial cell biology, angiogenesis and Nitric oxide research, and vascular reactivity. He/She is also expected to present results at laboratory meetings and participate in journal club presentations at St. Paul’s Hospital and/or UBC. This is a full-time position, available now. Students interested are invited to send their curriculum vitae to:
Dr. Pascal N. Bernatchez, Ph.D.Assistant-Professor, PharmacologyUniversity of British Columbia iCapture Heart and Lung Institute atSt-Paul's Hospital, Room 1661081 Burrard Street Vancouver, BC V6Z 1Y6Phone: (604) 682-2344 ext.66060Fax: (604) 806-9274pbernatch@mrl.ubc.capascal.bernatchez@gmail.com
Dr. Pascal N. Bernatchez, Ph.D.Assistant-Professor, PharmacologyUniversity of British Columbia iCapture Heart and Lung Institute atSt-Paul's Hospital, Room 1661081 Burrard Street Vancouver, BC V6Z 1Y6Phone: (604) 682-2344 ext.66060Fax: (604) 806-9274pbernatch@mrl.ubc.capascal.bernatchez@gmail.com
Graduate Student position in the iCAPTURE Center UBC
Project title: Understanding the role of fibroblast differentiation in Pulmonary Fibrosis
A graduate student position (Pharmacology) under the supervision of Dr. Darryl Knight is currently available. Applicants should hold an undergraduate degree in life sciences – preferably Pharmacology, Biochemistry or Cell Biology. The projects consist in developing new pharmacological approaches for the treatment of Idiopathic Pulmonary Fibrosis. More precisely, the successful candidate will be expected to deepen his understanding and perform experiments related to fibroblast biology, fibrosis and transcription factor research.
Brief Project Description:Idiopathic pulmonary fibrosis (IPF) is the most common form of idiopathic interstitial pneumonias and also the most unresponsive to current therapies. The enigmatic origins of IPF and our incomplete knowledge of the disease pathogenesis have made treatments entirely empirical. The end stage of the disease is characterized by aggressive lung remodelling, increased collagen synthesis and deposition, loss of lung function and premature death. Emerging evidence indicates that functionally distinct subsets of fibroblasts exist within the lung may play key roles in IPF, although the mechanisms underlying this diversity are unknown. We propose that lung fibroblast heterogeneity in IPF stems from an imbalance between apoptosis (quiet death) and cellular senescence (quiet survival) and that the transcription factor signal transducer and activator of transcription (STAT) 3 is a key element in fibroblast growth regulation and apoptosis. Based on funding from our previous grant, we made the exciting discovery that ability of lung fibroblasts to activate STAT3 is a crucial factor for the transition of fibroblasts into myofibroblasts - the cells primarily responsible for the deposition of collagen and other extracellular matrix proteins that characterize IPF.
Our data suggest promise in specific pharmacological manipulators of the STAT3 pathway that suppress pathological and fibrosis-prone myofibroblasts while leaving other mesenchymal and epithelial cells in the lung largely intact.The student will work with a faculty member and his research team, based at the James Hogg iCAPTURE centre for Cardiovascular and Pulmonary Research at St Pauls Hospital. The student will be involved with establishing and maintaining primary cultures of human lung cells obtained from healthy donors as well as patients with IPF. He/she will also participate in designing experiments to investigate a number of cell functions such as proliferation, apoptosis, expression of integrins, growth factor receptors and a-smooth muscle actin.
Students interested are invited to send their curriculum vitae to:Dr Darryl Knight, Rm 166, St Pauls Hospital, 1081 Burrard St Vancouver, V6Z 1Y6. Tel 604 682 2344 (x62217); dknight@mrl.ubc.ca
A graduate student position (Pharmacology) under the supervision of Dr. Darryl Knight is currently available. Applicants should hold an undergraduate degree in life sciences – preferably Pharmacology, Biochemistry or Cell Biology. The projects consist in developing new pharmacological approaches for the treatment of Idiopathic Pulmonary Fibrosis. More precisely, the successful candidate will be expected to deepen his understanding and perform experiments related to fibroblast biology, fibrosis and transcription factor research.
Brief Project Description:Idiopathic pulmonary fibrosis (IPF) is the most common form of idiopathic interstitial pneumonias and also the most unresponsive to current therapies. The enigmatic origins of IPF and our incomplete knowledge of the disease pathogenesis have made treatments entirely empirical. The end stage of the disease is characterized by aggressive lung remodelling, increased collagen synthesis and deposition, loss of lung function and premature death. Emerging evidence indicates that functionally distinct subsets of fibroblasts exist within the lung may play key roles in IPF, although the mechanisms underlying this diversity are unknown. We propose that lung fibroblast heterogeneity in IPF stems from an imbalance between apoptosis (quiet death) and cellular senescence (quiet survival) and that the transcription factor signal transducer and activator of transcription (STAT) 3 is a key element in fibroblast growth regulation and apoptosis. Based on funding from our previous grant, we made the exciting discovery that ability of lung fibroblasts to activate STAT3 is a crucial factor for the transition of fibroblasts into myofibroblasts - the cells primarily responsible for the deposition of collagen and other extracellular matrix proteins that characterize IPF.
Our data suggest promise in specific pharmacological manipulators of the STAT3 pathway that suppress pathological and fibrosis-prone myofibroblasts while leaving other mesenchymal and epithelial cells in the lung largely intact.The student will work with a faculty member and his research team, based at the James Hogg iCAPTURE centre for Cardiovascular and Pulmonary Research at St Pauls Hospital. The student will be involved with establishing and maintaining primary cultures of human lung cells obtained from healthy donors as well as patients with IPF. He/she will also participate in designing experiments to investigate a number of cell functions such as proliferation, apoptosis, expression of integrins, growth factor receptors and a-smooth muscle actin.
Students interested are invited to send their curriculum vitae to:Dr Darryl Knight, Rm 166, St Pauls Hospital, 1081 Burrard St Vancouver, V6Z 1Y6. Tel 604 682 2344 (x62217); dknight@mrl.ubc.ca
UBC Dept. Pharmacolofy TWO POSTDOCTORAL POSITIONS NOW AVAILABLE
Postdoctoral Fellow positions under the joint supervision of Dr. David Fedida and Dr. Steve Kehl are currently available. It is essential that applicants have an M.D. degree or Ph.D. in the physiology/pharmacology and/or biophysics of ion channels. The research positions require an understanding of, and demonstrated practical experience with voltage clamp of macroscopic or single channel currents from cultured cells, from acutely isolated cells or from Xenopus oocytes. Opportunities exist either to learn or to contribute to mathematical models of ion channel gating and/or voltage clamp fluorimetry. The projects will involve the molecular and electrophysiological characterization of structural changes in potassium channel function in a heterologous expression system and cell surface expression in the cardiac myocytes under a number of experimental conditions. The successful candidate will be expected to carry out electrophysiological experiments and data analysis on a day-to-day basis, in a relatively independent manner. He/She is also expected to present results at laboratory meetings, participate in journal club presentations, and prepare drafts of articles for publication. These are full-time positions, available now. Please send your curriculum vitae together with at least 3 contacts for references to:
Cardiovascular Research GroupAttn. Dr. Fedida or Dr. KehlDepartment of Cellular & Physiological Sciences,Life Sciences Centre2350 Health Sciences MallVancouver, B.C. V6T 1Z3CanadaEmail: fedida@interchange.ubc.caor skehl@interchange.ubc.ca
Cardiovascular Research GroupAttn. Dr. Fedida or Dr. KehlDepartment of Cellular & Physiological Sciences,Life Sciences Centre2350 Health Sciences MallVancouver, B.C. V6T 1Z3CanadaEmail: fedida@interchange.ubc.caor skehl@interchange.ubc.ca
UBC Science Research Career Opportunities
Tier II Canada Research Chair in Nanoscience
Departments of Chemistry and Physics and Astronomy
Chemistry and Physics and Astronomy invite applications from outstanding candidates for a joint CRC chair in the areas of nanoscience, quantum materials, surface science, inorganic solid state chemistry, and condensed matter physics.
Apply: Deadline for Applications: April 15, 2009
Science Education Postdoctoral Researcher
Carl Wieman Science Education Initiative in Life Sciences
The Council of Life Sciences, which is coordinating curriculum reform for the departments of Botany, Microbiology and Immunology, and Zoology at the University of British Columbia invites applications for postdoctoral researchers for the Carl Wieman Science Education Initiative in Life Sciences, a five-year program for study of and innovation in science education.
Apply: Position open until filled